ELECTRON MICROSCOPIC CHANGES OF PERITUBULAR MACROPHAGES OF RAT TESTIS UNDER CONDITIONS OF CENTRAL BLOCKAGE OF LUTEINIZING HORMONE SYNTHESIS BY TRIPTORELLIN DURING 90 DAYS OF OBSERVATION.

Introduction. Macrophages are cells of the innate immune system that play many roles in body. known to be found endocrine glands, and there is now much evidence these interact closely with cells. Immune-endocrine interactions important for development glands their functioning during physiological states, also become key players pathophysiological states. Through gene expression profiling, diverse subpopulations tissue macrophages have been identified organs; this has implications disease pathogenesis potential pharmacotherapy. The molecular basis relationship between being revealed, allowing identification numerous points pharmacological intervention. main testis, but origin, heterogeneity, not sufficiently studied.
 Object methods. study was conducted on 20 adult male rats. Animals were randomly divided into 2 groups: control (10 animals) intact animals). group injected solution a dose 0.3 ml. Preparation material electron microscopic examination structures interstitial space testis carried out according generally accepted method.
 Results discussion. We two populations located testes, considering location functional capacity. results our research showed under influence central blocking LH synthesis, morphogenesis antigen-presenting namely macrophages, occurs. These modifications indicate an inversion polarization, which, turn, leads reorganization cells, particular activation (M1) perform certain activities organ.
 Conclusions. In early stages metabolic disorders detected parenchyma stroma organ, which led signs ultrastructural stress, manifested itself quantitative shift macrophage population direction increase peritubular macrophages.